1. No One Is Here Except All Of Us by Ramona Ausubel: The whole tone of this novel is strange and different and almost fairy tale like, despite a setting that is anything but a fairy tale. It's hard to explain if you haven't read it, but it's very unique.
2. The Best Laid Plans (and its sequel The High Road) by Terry Fallis: Canadian political satire is not the kind of thing you find every day.... or at all. This book is also uproariously funny.
3. The Lovely Bones by Alice Sebold: The only book I've ever read told from the perspective of a dead girl.
4. Life of Pi by Yann Martel: Yes, I actually read it after listing it earlier as one of the books I was intimidated by. To tell the truth, I didn't love this book and after a while, I just wanted them to get off the darn boat, but there is no arguing that it was a unique perspective.
5. Sophie's World by Jostein Gaarder: It's a book.... but also a philosophy course. I liked this in high school, but should probably pick it up again.
6. The Gum Thief by Douglas Coupland: This was a gift, and I'm not usually big on novels told through letters, but this was pretty unique. A middle-aged man and young woman start writing to each other while working at Staples, but otherwise don't acknowledge they know each other at all. I enjoyed it.
7. Attachments by Rainbow Rowell: Boy falls in love with girl... by reading her private email. Loved it.
8. 419 by Will Ferguson: I didn't love this book, but the concept is intriguing. It's a look at the other side of those spam emails you get claiming you can make a fortune if only you collaborate with this lawyer in Nigeria. Quite thought provoking.
9. The Eyre Affair (and various sequels) by Jasper Fforde: You get to go inside your favourite books. Amazing!
10. State of Wonder by Ann Patchett: What made this book unique to me was the subject matter. It took you into the Brazilian jungle where scientists were at work developing a "wonder drug" for fertility. Very different and creative.